Endocrine Abstracts

Objective: Somatic mutations in the GNAS1 gene, which encodes the alpha-subunit of G stimulatory proteins (gsp), are frequently detected in somatotroph pituitary tumors and have been associated to specific clinical-smaller and less invasive tumors occurring in older patients- and histopathological-densely granulated adenomas- characteristics. However, the question whether the presence of a somatic gsp mutation affects the response to somatostatin analogue treatment remains unr...

Aim: Brown tumors are a very rare and serious complication of sustained undiagnosed secondary hyperparathyroidism. Diagnosis and differential diagnosis are made by combining clinical, biochemical, radiological and pathological findings. We present the case of a male with chronic renal disease and multiple bone damage.A 58-year-old male was referred to the endocrine clinic because of lower back and pleural pain. He was an obese smoker with a heavy medical...

Introduction: Medullary thyroid carcinoma (MTC) originated from parafollicular C cells of the thyroid gland is a rare histological type of malignancy. Common sites of metastases are liver, lungs and bones, while metastases in other sites are extremely rare. Breast metastases from MTC are reported in 20 cases, and only in women.Case report: A 67-year-old man was presented after thyroidectomy for further evaluation and treatment. Histology was positive for...

Introduction: Tyrosine kinase inhibitors (sorafenib and sunitinib) have been used in treating refractory cases of thyroid cancer. The aim of our present study was to assess the efficacy of these agents in patients with refractory and progressive thyroid cancer, regarding patients’ quality of life, adverse events and response ratesPatients and methods: We retrospectively analyzed data of adult patients with differentiated and medullary thyroid cancer...

Purpose: Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-I) are currently the principal biomarkers used to assess disease activity in acromegaly and any discrepancy between them renders interpretation of results inconclusive. The purpose of this study was to assess the frequency of discrepant results and identify parameters that might affect the emergence of this phenomenon.Methods: A systematic review of Medline and Scopus was performed (1987&...

Introduction: Women with non-metastatic breast cancer form a distinct subpopulation in which calcium homeostasis in response to treatment with denosumab has not been extensively investigated.Methods: Female patients with osteoporosis, who were eligible for treatment with denosumab, were prospectively enrolled (2011–2012) and divided into two groups; Group A consisting of patients with either no history or benign diseases non affecting bone metabolis...

BackgroundCystic parathyroid adenoma is a rare entity (<0.01% of all cervical masses) that leads to primary hyperparathyroidism in 9% of cases. Parathyroid scintigraphy is essential for the diagnosis although there are pitfalls with false negative results. Parathyroidectomy is the treatment of choice but its success depends on the exact preoperative localization of the parathyroid lesions. 4D-CT is a very helpful diagnostic tool in such cases.<p ...

Introduction: Somatostatin analogues (SSAs) are the mainstay of treatment for carcinoid syndrome (CS)-related symptoms. Controversy still exists regarding the extent of the efficacy of this intervention. The purpose of the systematic review and meta-analysis was to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of SSAs (lanreotide, octreotide, pasireotide) in patients with CS. Due to lack of uniformity and established criteria...